Be Aware/Beware of Lundbeck’s ’99 and me’

14 Jun

Shane, Lucy and ChrissyLundbeck, your not so friendly Pharma company are at it again in the Irish Isles. This time it’s the launch of a ‘new bipolar disorder campaign’ 99 and me.

What does the ’99 and me’ leaflet tell us? Well, let’s see: “Seeking help for symptoms of bipolar disorder is no cause for worry. Approximately 40,000 people in Ireland are currently being treated for the condition – that is approximately 1 in every 100 people in the country. Your healthcare professional is always on-hand to offer friendly advice and support. They can advise you on the right treatment pathway to suit you.”

The campaign, according to IrishHealth.com, ”aims to tackle misunderstandings about the condition, to remove the stigma surrounding it and to encourage people to get the treatment they need as soon as possible.” Dr Paul Scully of St James’s Hospital stated “not infrequently, bipolar can be misdiagnosed as depression and, as a result, patients don’t receive the treatment and support they need“.

Naturally Lundbeck have a treatment for bi-polar disorder. Unfortunately the treatment may be worse than the cure; will your hands-on friendly healthcare professional tell you that? Firstly there is Sycrest/Saphris which lists Akathisia as a ‘common’ side effect. Akathisia, you may know, is well known as the precursor to suicide and/or homicide.

Then there is Abilify. According to PharmaTimes the ‘National Institute for Health and Care Excellence’ (NICE) “has issued draft guidance recommending Lundbeck/Otsuka’s Abilify for the treatment of teenagers with bipolar disorder.” Remember Akathisia, particularly if this drug is prescribed to your teenager. The RxISK database has 348 reported deaths, 573 cases of Akathisia, 572 cases of Psychotic disorder, 381 cases of Agitation, 351 cases of Schizophrenia, 303 cases of mania, 303 cases of Delusion, 292 cases of Hallucination, 295 Suicide attempts, 293 Completed suicide and 276 cases of Aggression, all directly reported as an adverse effect of consuming Abilify. I could go on but you can have a look for yourself: RxISK (Abilify)

At the moment there is a Bi-polar Conference (13-16 June) ongoing in Florida. It’s called the ’10th International Conference on Bipolar Disorders’ and the listed disclosures would make your hair stand on end, here. Interesting to see the notorious pharma shill Charles Nemeroff in attendance. Despite the numerous conflicts of interest, at least in the US pharma declarations are listed, where-as Irish Psychiatrists and Doctors seem quite reticent in revealing their pharma connections. It would certainly be interesting to see what pharma connections, if any, Dr Paul Scully of St James’s Hospital has, including Lundbeck honoraria.

It should be noted; in my experience, if you or your loved one happen to have an adverse reaction (as listed above), your hands-on friendly GP will side with the pharmaceutical industry and turn their backs on you quicker than you can say ‘Judas Iscariot’.

When is a suicide not a suicide?

9 Jun
@AntiDepAware

This blog was written by Brian today. His blog ‘AntiDepAware‘ is such a revelation. His knowledge on prescription drug-induced deaths, coupled with brilliant investigational skills, surpasses no-one that I’m aware of.

It may come as no surprise that most of the victims in this particular blog were on Citalopram. Despite drug companies admitting that antidepressants (SSRIs in particular) can cause a person to commit suicide, Coroners seem to be lagging way behind in informing themselves. Have a read for yourselves:

When is a suicide not a suicide?

Robert Keywood was married and had two daughters, lived in Kent, and worked for Kimberley-Clark as director of human resources.

A few weeks before his death, he had travelled to Poland and America on business and was having trouble sleeping. He went to see his GP, and was prescribed sleeping tablets and antidepressants.

One Friday last November, Mr Keywood drove to the Pentagon shopping centre in Chatham, where he took his own life by jumping from the top of the multi-storey car park (right). A note left on the passenger seat of his car read: “You’re better off without me, love Bob.”Multi story

Ann, his wife of almost 30 years, told the inquest her husband had acted “agitated” and “out of character” on a number of occasions before he died.

CoronerDeputy assistant coroner Alison Summers (left) said, “One gleans some insight into a particular person’s life and it’s clear to me this was very out of character,” before recording a verdict of suicide.

To give a verdict of suicide, a coroner needs to be certain that the person intended to kill himself or herself. Often, the existence of a written note is regarded as evidence of intent. In this case, Mr Keywood had written just seven words on a piece of paper left in his car.

In a case where medication could well be the cause, however, it is surely relevant to ask the question: “Would the person have killed him/herself if he/she had not been taking medication?” In this case, like so many before it, Mr Keywood had no recorded history of depression, and only began to act agitated and out of character after having been prescribed medication. From the newspaper report, it would appear probable that an adverse reaction to antidepressants was responsible for Mr Keyword’s death. Therefore, unless there are circumstances that have gone unreported, suicide may not be the correct verdict in this case.

Like Mr Keywood, Trina Clinton, a 54-year-old housewife from Redditch, took her life by falling from a multi-storey car park in March 2005. Worcestershire Coroner Victor Round originally recorded a verdict of suicide but told the court that a blood test revealed the prescribed antidepressant Citalopram in Mrs Clinton’s blood.

After Mrs Clinton’s sister-in-law said that the antidepressant “must have been a contributory factor”, Mr Round changed the verdict to “suicide while under medication”. He then modified his verdict again to record an open verdict.

In the same month, Carwyn Lewisa 38-year-old air steward from Carmarthen, was found dead in a bath full of water with a travel case full of books on top of him. He had been suffering from depression for some time.

But the coroner said he could not record a verdict of suicide because of the possible side-effects of the antidepressant drugs that Mr Lewis had been taking. He recorded an open verdict.

Ian Fox, a 65-year-old retired postal worker from Edgware, died in July 2008 after throwing himself in front of a train at Finchley Road Tube station.

He had been prescribed the antidepressant Citalopram for just one month before taking his life and he had expressed a wish to come off it, complaining of confusion and anxiety.

At his inquest, Mr Fox’s wife blamed her husband’s sudden death on the medication, saying that her husband’s action was completely out of character. She described how, until he began taking Citalopram, he had only been suffering from mild depression, brought on by retirement from his job and a foot injury.

Coroner Dr Andrew Reid recorded a narrative verdict in which he accepted that Mr Fox had jumped in front of the train, but added: “I’m satisfied he did so while the balance of his mind was disturbed while suffering the adverse effects of Citalopram.”

Brian PalmerIn September 2011, self-employed electrician Brian Palmer (left), 63, from Littlehampton, visited his GP as a consequence of financial worries. He was prescribed Fluoxetine (Prozac) and Zopiclone. A few days later, Mr Palmer shot himself.

At the inquest, Mr Palmer’s widow Jennifer told the inquest that days after Mr Palmer began taking the drugs, his mental health deteriorated. She said: “I noticed a change in him almost straight after taking the pills. I asked to see the box in the days before but he said he couldn’t find it. I found it a few days after his death and it listed all the changes I had seen in him. My heart just stopped. I didn’t go down there with him, when he picked up the prescription – I wish I had. We have had to learn the hard way. I can’t bear to think of any other families going through this kind of trauma.”

Coroner Penelope Schofield recorded a narrative verdict, in which she concluded that Mr Palmer took his own life following the prescription of antidepressant pills.

In each of the four cases above, the deaths have been linked to the victims’ reactions to antidepressant medication. Yet two of the cases resulted in open verdicts, while in the other two, narrative verdicts were recorded.

My database also contains cases where coroners have turned a deaf ear to evidence pertaining to reaction to antidepressants. This was particularly noticeable in inquests into the Bridgend hangings.

At the inquest of Christopher Ward, for example, a police officer provided the information that 29 year-old Mr Ward “had been prescribed Citalopram for depression.” Even so, Coroner Peter Maddox declared that: “There was a lack of anything in the system that would have altered his judgement, you would expect him to understand what he was doing and the consequences,” said Mr Maddox. “I can’t ignore the circumstances in which he was found, the toxicology results which suggests he was in control of his faculties.” Mr Maddox recorded a verdict of suicide, thus completely ignoring the possibility that Citalopram may have “altered his judgement”.

Lana WilliamsIn the case of 20 year-old mother Lana Williams (right), her fiancé said she had seemed “in good spirits” when he had left the house for work on the morning of her death. A police officer reported that “although Miss Williams had suffered post-natal depression, for which she was still taking medication, there was no other history of mental health problems.” After hearing the evidence, “Coroner Peter Maddox said he thought an appropriate verdict was that Lana Williams took her own life.”

It has been proposed that there should be a separate verdict for those who have taken their lives while under the influence of prescribed medication. This would be a verdict of “Iatrogenic Suicide”, the word iatrogenesis being defined as an inadvertent adverse effect or complication resulting from medical treatment or advice. This would be supported by those who are concerned that suicide figures are underestimated due to the number of self-inflicted deaths registered as open or narrative verdicts.

On the other hand, Dr David Healy writes that: “If someone jumps to their death from a 10th floor balcony under the influence of LSD, unless there is clear evidence beforehand that this was what was planned, an open verdict would be more appropriate than a suicide verdict.”

SSRIs are capable of causing similarly tragic outcomes, and bereaved families who recognised that their loved one’s death was caused by a reaction to medication would be disappointed to receive a verdict of suicide in such cases.

Pharma advertising In Ireland

5 Jun

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It takes a lot to shock me nowadays, but I admit to being shocked by an article in todays Irish Independent. It reported here that cheese advertisements will have to carry a health warning in order to limit intake under new restrictions on advertising to children. Cheese will carry a health warning as part of a bid to tackle childhood obesity; yet antidepressants are handed out like bloody smarties and your friendly GP will not give you a health warning on the doubling of suicide and violence risk? That makes no sense.

Under EU legislation, Ireland does not permit ‘direct to consumer’ (DTC) advertising for prescription products. This is unlike in the US and New Zealand where DTC advertising is permitted. In the case of a TV advertisement in the US, it must include a “major statement” for prescription drugs. A major statement must include a ‘spoken’ presentation of the drug’s most important risks. According to the Food and Drug Administration (FDA), this must be done in a way that is clear, conspicuous, and neutral.  In addition, they must include either every risk or provide enough sources (adequate provision) for the audience to obtain the drugs prescribing information.

EU advertising restrictions must mean that Irish broadcasting must be safer for the consumer, right? Actually, it doesn’t seem so. Last week I watched an Advert on TV3 regarding ‘Centrine Allergy’ which is an ‘over the counter’ antihistamine made by Rowex pharmaceuticals in County Cork. Considering there was no listed side-effects, this advert seemed to imply that Centrine Allergy is pretty harmless, so I looked up the patient  information leaflet (PIL). The possible adverse effects of taking this antihistamine include depression, hallucination, aggression, extreme fatigue, agitation, rapid heart beat, swelling, changes in liver function,weight increase, convulsions, confusion, difficulty in sleeping, difficulty focusing, blurred vision, unusual eye movements, fainting, tremor, tics, pain and/or difficulty passing water and memory loss.

It could be argued that this medication should not have OTC status considering the dangerous side-effects which can occur with consumption. Surely the advert should, at the very least, include the serious side effects above? What about the safety of the unborn baby? Surely pregnant women should be advised, that as Rowex admit to ‘limited experience’ within pregnancy, their advise is to ‘use with caution’, and further, that Centrine allergy should not be used during breast-feeding.

I sent off a complaint to TV3 and got a swift response the following day. The response included “The advertisement to which you refer is entirely in accordance with all relevant regulation. There is no requirement under regulation to include all the possible side-effects of a medicinal product in an advertisement” and ”the advertisement clearly states through text at the bottom of the screen, that you should always read the label and to ask your pharmacist for further information. There was no attempt to mislead the public about the possible side effects of this medicine.” If this is the case, and there is no requirement to include all (or any) side effects with DTC pharma advertising, the regulations need further regulating! I sent my complaint and the TV3 reply on to the Broadcasting Authority of Ireland (BAI), so we’ll have to wait and see what happens next.

Centrine Allergy PIL here.

While I was trying to find the advertisement to record, I came across this one above, advocating for the ‘early diagnosis and treatment’ of Arthritis. It recommended sending off for a free information pack to ‘Arthritis Ireland’. Note the Pfizer logo on the bottom right. It seems their latest campaign to ‘raise awareness’ is in partnership with Pfizer, who just happen to be seeking EMA approval for their new Arthritis medication; now there’s a surprise! In Nov 2012 the FDA approved Pfizer’s Xeljanz (Tofacitinib) for patients with Arthritis. The EMA though rejected Pfizer’s initial application, concluding that the serious side-effects such as liver damage, certain cancers and gastro-intestinal perforations, meant that the ‘benefits did not outweigh the risks’. Pfizer was not to be deterred. Dr Yvonne Greenstreet, Pfizer’s senior vice-president of medicines development, stated “The re-examination process will enable us to seek to address the CHMP’s questions, and we will continue to work closely with the EMA with the goal of making this medication available to the appropriate patients in Europe.” Hmm; I get the feeling that ‘Arthritis Ireland’ is being used as a pawn by Pfizer in the EMA approval process. Only time will tell!

Automatism and the Insanity Defence

30 May

David Healy – Hearts and Minds- Psychotropic Drugs and Violence (30/04/2013)

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There is so much evidence that Psychotropic drugs can cause suicide and violence. Anyone who is considering their doctor’s advice recommending these drugs; please inform yourself of the possible consequences and watch this video first, courtesy of www.RxISK.org

Cases mentioned (In order):

Mat Miller (Age 13-Zoloft)

American woman – “GSK… Please don’t forget about me.”

Virginia Tech.

Sylvia Plath.

Joseph Wesbecker (Prozac)

Donald Schell (Paxil/Seroxat)

David Hawkins (Zoloft)

Merillee Bentley (Effexor)

M.C. (Paxil/Seroxat)

Leslie Demeniuk (Zoloft and Paxil/Seroxat)

David Rule (Citalopram)

Christopher Pittman (Age 12-Paxil/Seroxat and Zoloft)

Yvonne Woodley (Citalopram)

Sandy Hook

Daniele Canarelli (Psychiatrist found guilty)

My son Shane (Citalopram)

Psychiatric Meds and Mass Murder

23 May

Magic BulletThe Systemic Correlation Between Psychiatric Medications and Unprovoked Mass Murder in America.

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Here’s a very interesting paper: ‘The Systemic Correlation Between Psychiatric Medications and Unprovoked Mass Murder in America’ written by Jeanne M. Stolzer, Professor of Child and Adolescent Development at the University of Nebraska-Kearney in Nebraska. Click on the link at the top of the page to access the full pdf.

First paragraph…

“Since the beginning of the human race, violence has permeated every civilization in recorded history. However, over the last 10-15 years, violence of an unprecedented nature has become common place across America. Young male killers are opening fire in movie theatres, shopping malls, and schools with no apparent motivation. Innocent six- and seven-year-old American children are shot to death as they sit in their first grade classrooms. We as a nation are stunned, despondent, and angry. How could this happen? Why is this happening? How can we prevent such tragedy from occurring in the future? On December 17, 2012, President Barack Obama addressed the nation at a memorial service for the 20 first grade children and the six school employees who were shot to death at a public school in Newtown, Connecticut. The president of the United States consoled the American public and made it absolutely clear that change was needed in order to stop the senseless carnage that is occurring in America…….”

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LKMC Syndrome.

22 May

Lundbeck Killed My Child DisorderSo what’s happening this week in the depressing world of suicide and ‘mind altering drugs’?

The following was meant to be tongue in cheek but actually the subject is too serious and I miss my son too much to make light of this issue.

Did you hear there’s a new syndrome that’s just been confirmed? Yep, LKMS disorder aka ‘Lundbeck Killed My Son’ Disorder. I suppose if I was being fair, it should be called ‘LKMC’ aka ‘Lundbeck killed my Child’ Disorder. There are many of us affected by this virus, although thankfully it isn’t contagious.

It should be noted that LKMC disorder is a global problem, not just restricted to Ireland or the UK. In fact America, New Zealand and China are reporting an ever-increasing rate of suicide. I have previously shown that the unsuspecting Chinese are killing themselves at an alarming rate, most likely due to the relatively new ‘depression’ advertisements, pushed by dubious pharmaceutical companies including Lundbeck, here.

The latest news regarding the DSM-5 is that grief for more than 2 weeks, even after the death of a loved one, can be seen as a symptom of Major Depressive Disorder, here. Considering that Shane is dead almost four years and I can still blubber like a lunatic at the worst possible moments; that surely means I’m decidedly unwell. I wonder if a pill could cure the death of my son? Can they miraculously make him re-appear? Even your toddler’s ‘temper tantrums’ may be diagnosed as an illness under the new and ‘unimproved’ DSM-5 and therefore medicated accordingly.

This week researchers from Duke University reported that antidepressants, including Lundbeck’s Lexapro appears to help prevent a potentially serious stress-related heart condition. You can find the study in ‘The Journal of the American College of Cardiology’ here. I’d list the conflicts of interests but there isn’t enough room on the page. You can access them yourself by clicking the ‘Author Information’. Now you will have to pardon my stupidity here, but surely these researchers know that Lexapro causes heart-attacks and sudden death? The FDA sent out a warning letter to all practitioners advising of the risk of heart problem with Citalopram in August 2011. This was revised in March 2012 to include Escitalopram, which is no surprise as they’re basically the same drug (as found in a Brussel’s Court here).

Lundbeck whose patents (and patience) are running out, have been frantically scrambling around for their next block-buster drug. Vortioxetine aka Brintellix is their latest offering.  Data concerning Vortioxetine efficacy was presented at the 2013 American Psychiatric Association Annual Meeting (APA). 4 trial results were shown, 3 for and 1 against. It’s the 1 against that I would be interested in. Was there any deaths? There was certainly a death in one of the Citalopram trials. Are they going to publish all the Vortioxetine trials as GSK are supposed to be doing? Actually no, ignore that, GSK backtracked on that particular promise!

We will have to wait and see whether Vortioxetine will get a ‘licence to kill’ by the FDA and the EMA, and if so, whether it will add to the growing cases of LKMC disorder.

Two more young people dead; victims of a broken system?

11 May

Kieran and AlexandraSadly today’s newspapers report that a body recovered from the River Foyle has been identified as missing Dublin teenager Kieran McKeon. He was 18 years old.

Last March (13th) Kieran travelled to Derry with his friend Alexandra O’Brien (21) and checked into a nearby hotel. The following day some of Alexandra’s belongings were found on a bridge over the River Foyle. Following the recovery of her body, the PSNI also feared for Kieran’s safety. It was largely believed that they had both entered the water together from the Foyle Bridge. Tragically Kieran’s body was recovered on Thursday and identified today.

The Irish Times reported in March: “Alexandra and Kieran were both day patients at St John of God’s, which specialises in treating people with mental health problems. In their original missing-person description of Ms O’Brien, the PSNI described her as “vulnerable.”

Now, considering they were both patients of St John of God hospital, there is no doubt that they were medicated. The Irish ‘medical model’ did not save these two young people and in my humble opinion, probably caused or at least contributed to their deaths. Yes young people can be vulnerable. Yes people die by suicide without being medicated BUT young people are far more susceptible to the adverse-effects of psychiatric drugs. Were these young people or their families warned of the doubling of the suicide risk? Were they told that these drugs were not recommended for young people, or that the EU warning on these drugs was upped to under 25s because of the suicide risk? I have first hand experience of Irish Psychiatrists denying that these drugs can cause suicide. They are wrong! The US has a black-box warning on these drugs because of the serious repercussions, particularly in young people.

FDA confirms risks of antidepressants.

Baum Hedlund, A cure worse than the disease.

Here is a 1991 you-tube video on the dangers of SSRIs; listen to these people’s stories if you dare/care. Despite this FDA hearing, it was another 13 years (2004) before they finally put a black-box warning in place for Under 18s. It took another 3 years (2007) before the US upped the warning to Under 24s; the EU followed suit upping the suicide warning to U25s. Yet the EU and the Irish Medicines Board declined to put a black-box warning on the same drugs for fear that it would “stop people from taking drugs that were perfectly suited to them”. Never mind the poor people who lost their lives by taking them!

Sadly this still hasn’t stopped uninformed doctors from medicating young people. It still hasn’t stopped suicide awareness groups from accepting funding from the makers of drugs which cause suicide; you know who you are. Is it any wonder when there are psychiatrists, like Dr Moosajee Bhamjee on Newstalk radio, who said that the suicide warnings were only put in place because of ‘the media and other issues’. Then again, the person who could have acted on this is Minister Kathleen Lynch. Remember Professor Healy and Declan Gilsenan’s meeting with her? David Healy told her that these drugs are the leading cause of death within the mental health field. Dr Gilsenan told her he had serious concerns that these drugs were causing people to kill themselves. Has she done anything? Yet again, NO! Shame on her.

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